Malacoplakia is an uncommon granulomatous inflammatory condition that can affect various organs with predilection for the genitourinary tract, especially urinary bladder.
Soft plaque resulting from defective macrophage function can be seen in various organ.
This condition has peak incidence in middle age with female predilection (4:1).
Associated with immunosuppression, infection and systemic illnesses.
- Symptom
- Fever, flank pain and a palpable mass
- Imaging finding
- Variable ⇨ multiple, polypoid, vascular, solid masses
- Vary in size from a few millimeters to several centimeters
- Occasionally, locally aggressive and invades surrounding structures even causing bone erosions
- Treatment of malakoplakia
- Unifocal diseases
- Surgical excision is the choice treatment
- Bilateral or multifocal
- Typically cured after using quinolones, rifampin, doxycycline and/or vancomycin in combination with a cholinergic agonist such as bethanechol chloride.
- Unifocal diseases
biopsy confirmed as malacoplakia.
biopsy confirmed as malacoplakia.
References)
Purnell SDK, et al. BMJ Case Rep 2015. doi:10.1136/bcr-2014-208652
Korean J Med 2017;92:476-479
Urology Case Reports 17 (2018) 117e118
Can UrolAssoc J 2018 July 24
