Castleman disease radiology

DEFINITION
Castleman disease is an uncommon benign B-cell lymphoproliferative disorder.

TERMINOLOGY
= angiofollicular lymph node hyperplasia
= giant lymph node hyperplasia

1) Hyaline vascular type (90%)
– Unicentric castlman disease
– Before 30s, no symptom
– Single mass or mediastinal/hilar lymph node enlargement
– Localized disease
– No progression to non-hodgkin lymphoma
– Mediastinal or hilar mass/LNE with marked enhancement ± calcifications

2) Plasma cell type (10%)
– Multicentric disease
Systemic Sx (fever, organomegaly)
    Progression to NHL
    Asso. with HIV or HHV-8 positive
    Multiple lymphadenopathy
    May involve lung parenchyma
(centrilobular nodules, bronchovascular bundle/interlobular septal thickening, thin-walled cyst)

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