Anomalous origin of coronary artery: Uncommon but important anomaly at high risk of sudden cardiac death

I will introduce 2 cases of anomalous origin of coronary artery from opposite or noncoronary sinus

Case 1) Male, 62 years old presented with chest pain

1) Right coronary artery originates from left sinus of valsalva, its course is called interarterial course

2) Curved multiplanar image shows the interarterial course of RCA (A : Aorta, PA : Pulmonary artery)
3) Volume rendered image, interarterial course of RCA

Case 2) Male, 59 years old follow up coronary CT angio after percutaneous coronary intervention

1) Anomalous Left Coronary Artery Originating from upper portion of right sinus of the valsalva (high take off), Above the junctional zone (tubular part of ascending aorta and sinus – sinotubular junction)

2) Schematic diagram of ascending aorta, Image from ‘https://commons.wikimedia.org

3) Curved multiplanar image(left) / volume rendered image(right), Anomalous Left Coronary Artery Originating from upper portion of right sinus of the valsalva (high take off), above the junctional zone

Origin of the coronary artery or branch from opposite or noncoronary sinus and an anomalous course

  • RCA arising from the left coronary sinus
  • LCA arising from the right coronary sinus
  • LCx or LAD arising form the right coronary sinus
  • LCA or RCA arising from the noncoronary sinus
  • In these anomalies, the coronary ostium may be at the normal level, or the involved artery may have a high takeoff

4) (a) interarterial (ie, between the aorta and the pulmonary artery), (b) retroaortic, (c) prepulmonic, or (d) septal (subpulmonic), Image from Radiographics. Mar-Apr 2006;26(2):317-33;

Figure 4) shows possible courses of the anomalous coronary artery, note that ‘interarterial course (a)’ can be associated with sudden cardiac death

The possible mechanism of sudden cardiac death is when dilation of the aorta occurs during exercise, the anomalous slit-like ostium for the RCA in the left sinus becomes narrower, possibly limiting coronary blood flow and resulting in myocardial infarction

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