DEFINITION
Castleman disease is an uncommon benign B-cell lymphoproliferative disorder.
TERMINOLOGY
= angiofollicular lymph node hyperplasia
= giant lymph node hyperplasia
1) Hyaline vascular type (90%)
– Unicentric castlman disease
– Before 30s, no symptom
– Single mass or mediastinal/hilar lymph node enlargement
– Localized disease
– No progression to non-hodgkin lymphoma
– Mediastinal or hilar mass/LNE with marked enhancement ± calcifications
2) Plasma cell type (10%)
– Multicentric disease
Systemic Sx (fever, organomegaly)
Progression to NHL
Asso. with HIV or HHV-8 positive
Multiple lymphadenopathy
May involve lung parenchyma
(centrilobular nodules, bronchovascular bundle/interlobular septal thickening, thin-walled cyst)